Which Rpb subunits are auxiliary?

Overview of RNA Polymerase II Structure

RNA Polymerase II (Pol II or Rpb) is a crucial enzyme involved in the transcription process, where DNA is converted into RNA. It is a complex enzyme composed of several subunits, both core and auxiliary.

Core and Auxiliary Subunits

In eukaryotes, RNA Polymerase II typically comprises 12 subunits. The core subunits are essential for the polymerase activity and directly involved in catalyzing transcription. On the other hand, auxiliary subunits are not required for catalysis but play regulatory roles or help to stabilize the complex.

Rpb4 and Rpb7 as Auxiliary Subunits

Rpb4 and Rpb7 are among the auxiliary subunits of RNA Polymerase II. They are known to be involved in various aspects of the enzyme's function, such as transcript elongation under specific conditions, RNA processing, and response to stress.

Conclusion

In summary, while the core subunits of RNA Polymerase II are essential for catalyzing transcription, the auxiliary subunits like Rpb4 and Rpb7 contribute to the overall regulatory and stabilization functions of the enzyme complex.