The Importance of Mitotic Checkpoint in Cell Division

What is the significance of the mitotic checkpoint in the cell cycle?

A. To ensure proper DNA replication B. To regulate cell growth C. To check for correct spindle attachment to chromosomes D. To initiate cell division

Answer:

C. To check for correct spindle attachment to chromosomes

The mitotic checkpoint in the cell cycle plays a crucial role in ensuring the proper segregation of chromosomes during cell division. This checkpoint occurs between metaphase and anaphase, where it checks for the correct attachment of chromosomes to the spindle fibers. Proper attachment is essential to prevent errors in chromosome segregation, which can lead to genetic instability and diseases such as cancer.

During metaphase, all chromosomes should align along the metaphase plate and attach to the spindle fibers before they are separated during anaphase. If any chromosome is not properly attached, the mitotic checkpoint will delay the progression of the cell cycle until the issue is resolved. This mechanism helps maintain the genomic integrity of the cell by preventing the unequal distribution of genetic material to daughter cells.

The mitotic checkpoint is a critical quality control mechanism that ensures the fidelity of chromosome segregation and the accurate distribution of genetic material during cell division. Failure to properly regulate this checkpoint can result in chromosomal abnormalities and contribute to tumorigenesis. Understanding the importance of the mitotic checkpoint can provide insights into the molecular mechanisms underlying cell division and disease development.